China (Mainland)
HS-173; Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate CAS NO.1276110-06-5
- Min.Order: 1 Gram
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- Product Details
Keywords
- 1276110-06-5
- HS-173
- Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate
Quick Details
- ProName: HS-173; Ethyl 6-(5-(phenylsulfonamido)...
- CasNo: 1276110-06-5
- Molecular Formula: C21H18N4O4S
- Appearance: white solid powder
- Application: For research only.
- DeliveryTime: Within 3 days after payment
- PackAge: as required
- Port: Beijing or Guangzhou
- ProductionCapacity: 100 Gram/Month
- Purity: 98%
- Storage: Dry, dark and at 0 - 4 C for short ter...
- Transportation: Shipped under ambient temperature as n...
- LimitNum: 1 Gram
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Details
CAS No.：1276110-06-5
LAL ID：xqy-170108
Chemical Names: HS-173; Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate
Molecular Formula: C21H18N4O4S
Molecular Weight: 422.459 g/mol
Purity: 98%
The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%.
Description: HS-173 is a potent PI3Kα inhibitor with potential anticancer activity. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients.